Zeta Reticuli is located in the southern hemisphere of the Milky Way galaxy, within the constellation Reticulum.

It's important to note that "southern hemisphere" in this context refers to the Milky Way's disc, not the Earth's. While the system is visible from Earth's southern hemisphere, it's positioned in the galaxy's southern hemisphere relative to the Milky Way's galactic center.

Zeta Reticuli is approximately 110 light-years away from Earth.