High-speed atomic force microscopy (HS-AFM) allows scientists to directly visualize biomolecular dynamics in real time. Here, the researchers captured the dancing motion of a short RNA molecule with its partner drug molecules under physiological conditions. The movies revealed that the drug molecules bind and rotate around the RNA in a highly dynamic manner, enabling them to target the specific RNA structure and function. This study provides a better understanding of how drugs interact with RNA and offers new insights into the development of RNA-targeted therapeutics.