42 degrees north latitude and 80 degrees west longitude is located in the Niagara Falls region of New York State, USA.

Here's a more detailed breakdown:

* Niagara Falls: The iconic waterfalls themselves are very close to this coordinate, though slightly south and west.

* Niagara Falls, New York: This is a city on the US side of the falls, located very close to the given coordinate.

* Niagara County, New York: The coordinate falls within this county, which is home to Niagara Falls and its surrounding area.

You can easily find this location on a map using these coordinates.