The two high-energy molecules produced in the light-dependent reactions and consumed in the Calvin cycle are:

1. ATP (adenosine triphosphate): This molecule is the universal energy currency of cells. It provides the energy needed for the Calvin cycle to convert carbon dioxide into sugar.

2. NADPH (nicotinamide adenine dinucleotide phosphate): This molecule is a reducing agent, meaning it carries electrons. It provides the reducing power needed for the Calvin cycle to reduce carbon dioxide and ultimately form glucose.