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  • 4-Aminophenol + Acetic Anhydride Reaction: Product & Mechanism
    The product of the reaction between 4-aminophenol and excess acetic anhydride is 4-acetamidophenol, also known as paracetamol or acetaminophen.

    Here's a breakdown of the reaction:

    * 4-aminophenol has an amino group (-NH2) and a hydroxyl group (-OH) on the benzene ring.

    * Acetic anhydride is a reagent that adds acetyl groups (-COCH3) to molecules.

    The reaction proceeds as follows:

    1. Acetylation of the amino group: The amino group in 4-aminophenol reacts with acetic anhydride to form an amide bond, resulting in the formation of an acetamide group (-NHCOCH3).

    2. Acetylation of the hydroxyl group: In the presence of excess acetic anhydride, the hydroxyl group also reacts with the reagent to form an ester bond, resulting in an acetate group (-OCOCH3).

    Since excess acetic anhydride is used, both the amino and hydroxyl groups will be acetylated, leading to the formation of 4-acetamidophenol (paracetamol).

    Reaction Equation:

    4-Aminophenol + 2 Acetic Anhydride → 4-Acetamidophenol + 2 Acetic Acid

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