Here's why:
* Glucose (C6H12O6) is a 6-carbon molecule that is broken down into two 3-carbon molecules of pyruvate during glycolysis.
* Each pyruvate enters the Krebs cycle and is decarboxylated twice (losing a carbon atom as CO2).
* Therefore, two turns of the Krebs cycle (one for each pyruvate) produce a total of 6 CO2 molecules.