Proteins are more resistant to acid hydrolysis than nucleic acids. Here's why:

* Bond Strength: The peptide bonds in proteins are relatively strong and require significant energy to break. In contrast, the phosphodiester bonds in nucleic acids are weaker and more susceptible to hydrolysis.

* Structure: Proteins have a more compact and stable three-dimensional structure, which protects the peptide bonds from attack by acid. Nucleic acids, on the other hand, have a more open and flexible structure, making their phosphodiester bonds more accessible to hydrolysis.

* Sensitivity to pH: Proteins can tolerate a wider range of pH values than nucleic acids. While both molecules are sensitive to extreme pH conditions, nucleic acids are particularly vulnerable to degradation at low pH (acidic conditions). This is because the acidic environment can protonate the phosphate groups in nucleic acids, making them more susceptible to hydrolysis.

In summary: Proteins are more resistant to acid hydrolysis than nucleic acids due to the stronger peptide bonds, more stable structure, and higher tolerance for acidic environments.