General terms:
* Biological mystery: This is a good general term for any unsolved problem or phenomenon in biology.
* Biological enigma: Similar to "mystery," but with a stronger sense of something that is perplexing and difficult to understand.
* Biological conundrum: This emphasizes the difficulty and complexity of the problem.
* Biological challenge: This highlights the need for research and investigation to solve the problem.
More specific terms:
* Evolutionary puzzle: For problems related to the evolution of life.
* Genetic puzzle: For problems related to the structure and function of genes.
* Developmental puzzle: For problems related to how organisms develop from embryos.
* Ecological puzzle: For problems related to the interactions between organisms and their environment.
Examples of biological puzzles:
* The origin of life: How did life on Earth arise from non-living matter?
* The evolution of complex organisms: How did simple organisms evolve into complex ones like humans?
* The function of the human brain: How does the brain give rise to consciousness, thought, and emotion?
* The causes of cancer: How do cells become cancerous and how can we prevent and treat it?
Ultimately, the best term to use depends on the specific context and the nature of the biological puzzle you're referring to.