The first enzyme to mix with food in the digestive system is salivary amylase.

Here's why:

* Location: Salivary amylase is found in saliva, which is produced by the salivary glands in your mouth.

* Function: Salivary amylase begins the breakdown of carbohydrates (starches) into simpler sugars, making them easier to digest.

* Timing: This process starts as soon as you begin chewing your food, making salivary amylase the first enzyme to encounter your meal.