While there isn't a single "brightest" city, Las Vegas is often cited as one of the brightest cities visible from space due to its concentration of bright lights and casinos.

However, it's important to remember that:

* Brightness is subjective: It depends on factors like the angle of observation, atmospheric conditions, and the sensitivity of the observer's equipment.

* Many cities are bright: Large cities like Los Angeles, New York City, Tokyo, and London also generate a significant amount of light pollution and are visible from space.

Ultimately, the "brightest" city from space is a matter of perspective and definition.