Addressing this issue, a research team led by Dr. Yuan Chen from the Hefei Institutes of Physical Science, Chinese Academy of Sciences, in collaboration with colleagues from Southeast University and the University of Queensland, has developed a strategy to enhance the mechanical properties and durability of hydrogels for artificial tendon applications. Their findings are published in the journal Materials Today Bio.
The researchers employed a double-network hydrogel system based on poly(ethylene glycol) (PEG) and poly(acrylic acid) (PAA). The PEG network provided elasticity, while the PAA network contributed toughness and strength. By optimizing the composition and crosslinking conditions, they achieved a synergistic effect that significantly improved the mechanical performance of the hydrogels.
To further enhance durability, the team introduced a dynamic covalent crosslinking mechanism using Diels-Alder chemistry. This approach allowed for reversible bond formation and exchange within the hydrogel network, enabling self-healing and adaptability to mechanical stress.
The researchers tested the performance of their hydrogels in vitro and in vivo. Tensile testing demonstrated that the tough double-network hydrogels exhibited high strength and extensibility, comparable to natural tendons. Furthermore, in vivo implantation studies in rats showed excellent biocompatibility and long-term functionality of the artificial tendons.
Dr. Chen highlights the significance of their work: "Our study provides a promising approach for fabricating durable artificial tendons using tough double-network hydrogels with dynamic covalent crosslinking. Such materials hold great potential for clinical applications in tendon repair and reconstruction, offering new avenues for the treatment of tendon injuries."
