The major science that studies forces, motion, and energy effects on matter is physics.

Here's why:

* Forces: Physics deals with fundamental forces like gravity, electromagnetism, and the strong and weak nuclear forces, which govern how objects interact.

* Motion: Physics explores how objects move, including concepts like velocity, acceleration, and momentum.

* Energy: Physics studies different forms of energy, such as kinetic, potential, and thermal energy, and how energy is transferred and transformed.

While other sciences like chemistry and biology also involve these concepts, physics provides the foundational framework for understanding them at a fundamental level.