The muzzle velocity of a 45 ACP round can vary depending on the firearm, ammunition, and barrel length. However, a typical muzzle velocity for a 45 ACP round fired from a 5-inch barrel is around 850 feet per second (259 meters per second). This can vary from around 700 fps (213 mps) to over 1000 fps (305 mps) depending on the specific combination of firearm and ammunition.