- Subarctic climate (Köppen climate classification Dfc).
- Due to its inland location, the Klondike region experiences larger swings in temperature, with very cold winters and warm, dry summers.
- The warmest month is July with an average temperature of 18.6 °C, while the coldest is January, with an average of −18.7 °C.
- The average annual temperature is −3.5 °C.
- The average annual precipitation is 361.2 mm, the majority falling in the form of snow.
- The Klondike region is in USDA Plant Hardiness Zone 2, meaning that only the hardiest plants will survive outdoors year-round.