There are approximately 2.20462 pounds in one kilogram. To convert 72.1 kilograms to pounds, you can multiply 72.1 by 2.20462. Here is the calculation:

$$72.1 \text{ kg} \times 2.20462 \text{ lb/kg} \approx 159.054 pounds$$

Therefore, 72.1 kilograms is approximately equal to 159.054 pounds.