It's tricky to pinpoint three major cities *specifically* on the Ozark Plateau, as many large cities lie near its edge or in surrounding regions.

However, here are three cities that are closely tied to the Ozark Plateau and represent its cultural and economic significance:

1. Springfield, Missouri: Located in the heart of the Ozark Mountains, Springfield is the largest city in the plateau region and offers a vibrant blend of history, culture, and natural beauty.

2. Fayetteville, Arkansas: Situated at the edge of the Ozark Plateau, Fayetteville boasts a thriving university town atmosphere and a strong connection to the region's outdoor recreational opportunities.

3. Branson, Missouri: Known as the "Live Music Show Capital of the World," Branson is a major tourist destination deeply connected to the Ozark Plateau's natural wonders and cultural heritage.

It's important to note that the Ozark Plateau is a large and diverse region, with many other significant cities in its vicinity, such as Joplin, Missouri, and Fort Smith, Arkansas.