It is situated on the Mississippi River Delta, at the mouth of the Mississippi River, where it empties into the Gulf of Mexico.

Here are some key points about its location:

* Bordering Parishes: It borders St. Bernard Parish to the north and Jefferson Parish to the west.

* Major Cities: The parish includes the towns of Buras, Port Sulphur, and Venice, which is located at the very end of the Mississippi River Delta.

This location makes Plaquemines Parish particularly vulnerable to hurricanes and coastal erosion.