The 2.7-meter-high stone sculpture, which dates to the 15th century, depicts the goddess with a skirt of writhing snakes, a necklace made of human skulls, and a pair of severed hands clasped in her belt.
She was found by a farmer in the 18th century and was kept in the basement of the National Museum of Anthropology in Mexico City. The museum's director, Diego Prieto Hernandez, said the statue would now be placed in a "worthy" space on the museum's main floor.
"This is a very important moment for the National Museum of Anthropology because with the exhibition of this great sculpture we are completing the main collection of sculptures of Mexica culture," he said.
Coatlicue is one of the most important gods in Aztec mythology, and represents both the earth and death. The sculpture is known for its intricate detail and its powerful, almost terrifying, presence.
The statue will be on display starting March 18, 2018.