The organelle responsible for making energy stored in high-energy compounds available for the cell is the mitochondrion.

Here's why:

* Mitochondria are often referred to as the "powerhouses of the cell" because they are the primary site of cellular respiration.

* Cellular respiration is the process of breaking down glucose (a high-energy compound) in the presence of oxygen to produce ATP (adenosine triphosphate).

* ATP is the primary energy currency of the cell, and it is used to power various cellular processes.

Let me know if you'd like more details on cellular respiration!