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  • Where Chemical Digestion Happens: From Mouth to Duodenum

    By Cameron Delaney Updated Aug 30, 2022

    Anetlanda/iStock/GettyImages

    Chemical digestion is the process by which acids, enzymes, and secretions break down food into absorbable nutrients. While the journey starts in the mouth, the majority of enzymatic activity takes place in the small intestine.

    Mechanical vs Chemical Digestion

    Mechanical digestion—chewing and stomach churning—prepares food for enzymatic action.

    Stage 1: The Mouth

    Salivary amylase begins carbohydrate breakdown.

    Stage 2: The Stomach

    Hydrochloric acid creates an acidic environment; pepsin initiates protein digestion.

    Stage 3: The Small Intestine

    Pancreatic enzymes and bile salts further break down carbohydrates, proteins, and fats. The duodenum is the primary site.

    Why It Matters

    Chemical digestion converts macronutrients into sugars, amino acids, and fatty acids that the body can absorb and use for energy, growth, and repair.

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