* Liver: This is a major player in making new substances. It produces bile to help digest fats, creates proteins for blood clotting, and helps detoxify the body.
* Pancreas: This organ creates insulin and glucagon, hormones that regulate blood sugar. It also produces digestive enzymes.
* Stomach: It produces hydrochloric acid, which is crucial for digestion.
* Small Intestine: This organ produces enzymes to break down food.
* Kidneys: They produce hormones that regulate blood pressure and red blood cell production.
* Bone Marrow: This is where blood cells are made.
* Endocrine Glands: These glands, like the thyroid and pituitary gland, produce hormones that control various bodily functions.
So, the answer to your question depends on what type of new substance you're asking about. If you can be more specific, I can give you a more precise answer!