Here's a breakdown of why:

* Picric acid is a powerful explosive: Picric acid is a highly energetic compound and can detonate under the right conditions.

* Alkaline conditions increase instability: When picric acid is dissolved in a basic solution (like sodium hydroxide), it forms picrates, which are even more unstable than the acid itself. This is because the picrate anion is a powerful nucleophile and can easily react with other compounds, leading to decomposition.

* Formation of salts: Picrates readily form salts with metals, especially heavy metals like lead or mercury. These salts are even more sensitive to shock and heat, making them even more dangerous.

Therefore, it's crucial to prepare alkaline picrate solution only when needed and to use it immediately.

Safety precautions when handling picrates:

* Always wear appropriate personal protective equipment (PPE), including gloves, eye protection, and lab coat.

* Handle picrates with extreme care, avoiding any form of shock, friction, or heat.

* Store picric acid and picrate solutions in a cool, dry, and well-ventilated area, away from any potential sources of ignition or heat.

* Dispose of picrates properly according to local regulations.

Remember: Never attempt to prepare or handle picrates without proper training and safety protocols in place.