Helium is a noble gas, which means it is very unreactive. This is because it has a full outer shell of electrons, making it very stable and unlikely to gain or lose electrons. Therefore, helium generally does not react with other chemicals.

However, under extreme conditions, such as high pressure and temperature, helium can react with some elements. For example, it can form compounds with some metals, such as sodium, potassium, and rubidium, to form helium-containing salts.

But in normal conditions, helium is considered inert and does not readily participate in chemical reactions.