Both smooth and rough endoplasmic reticulum (ER) are involved in the production of proteins, but they have different roles in the process.

Here's a breakdown:

* Rough ER: The "rough" appearance comes from ribosomes attached to its surface. These ribosomes synthesize proteins, and the rough ER helps fold, modify, and transport these proteins.

* Smooth ER: While it doesn't have ribosomes, the smooth ER plays a crucial role in the processing of proteins synthesized by the rough ER. It also synthesizes lipids and steroids, detoxifies harmful substances, and regulates calcium levels in the cell.

Therefore, the primary macromolecule produced by both smooth and rough ER is protein. However, their specific roles in protein synthesis and other cellular processes differ.