You're very close! The change that takes place when two or more substances interact to form new substances is called a chemical reaction.

Here's why:

* Chemical reaction: Involves the breaking and forming of chemical bonds, leading to the creation of entirely new substances with different properties.

* Reaction: While this term can be used more generally, it's often more specific to refer to a chemical reaction in chemistry.

Let me know if you'd like more examples of chemical reactions!