Pearls are made of calcium carbonate, the same material as chalk and limestone. Here's the breakdown:

* Strong Acids: Acids like hydrochloric acid (HCl) will dissolve calcium carbonate, effectively "melting" the pearl.

* Other Solvents: While not technically melting, strong bases like sodium hydroxide (NaOH) will also dissolve calcium carbonate.

Important Note: These are strong chemicals and handling them requires proper safety precautions and equipment.

It's important to remember that melting a pearl is not a practical or desirable outcome. Pearls are beautiful and valuable, and their unique properties are preserved in their solid form.