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  • Understanding RNA's Negative Charge: A Detailed Explanation
    RNA, like DNA, carries a negative net electrochemical charge. This is due to the presence of phosphate groups in its backbone.

    Here's why:

    * Phosphate groups: The backbone of RNA is made up of alternating sugar (ribose) and phosphate groups. Each phosphate group carries a negative charge.

    * Sugar-phosphate backbone: The sugar-phosphate backbone is responsible for the overall negative charge of RNA.

    * Nitrogenous bases: The nitrogenous bases (adenine, guanine, cytosine, and uracil) are relatively neutral in charge.

    Therefore, the overall charge of RNA is negative due to the presence of multiple negatively charged phosphate groups in its backbone.

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