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  • Lederer-Manasse Reaction: Converting Phenol to p-Hydroxybenzaldehyde
    The Lederer-Manasse reaction converts phenol into p-hydroxybenzaldehyde.

    Here's how it works:

    * Phenol reacts with formaldehyde in the presence of a base catalyst (like NaOH).

    * The formaldehyde undergoes electrophilic aromatic substitution with the phenol.

    * The initial product is a hydroxymethylphenol, which undergoes further reaction with formaldehyde to form p-hydroxybenzaldehyde.

    The reaction can be summarized as:

    Phenol + Formaldehyde → p-Hydroxybenzaldehyde

    This reaction is important in organic chemistry for the synthesis of various aromatic compounds, including pharmaceuticals and dyes.

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