* Solubility is highly specific: What dissolves in one solvent might not dissolve in another. For example, salt dissolves well in water but not in oil.
* Polarity matters: Solvents can be polar (like water) or nonpolar (like oil). Generally, polar solutes dissolve in polar solvents, and nonpolar solutes dissolve in nonpolar solvents. This is the "like dissolves like" rule.
* Other factors: Temperature, pressure, and the presence of other solutes can also influence solubility.
To answer your question, tell me what solvent you are interested in, and I can give you some examples of solutes that might not dissolve in it.
