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  • Nucleolus Disintegration: Timing and Process During Mitosis
    The nucleolus begins to disintegrate during prophase, the first stage of mitosis.

    Here's why:

    * The nucleolus is a structure within the nucleus responsible for ribosome synthesis. During prophase, the nuclear envelope breaks down, allowing the chromosomes to condense and move freely within the cell.

    * The disintegration of the nucleolus is a consequence of the breakdown of the nuclear envelope. The nucleolar components disperse throughout the cytoplasm, and ribosome synthesis is temporarily halted.

    * The nucleolus will reassemble during telophase when the nuclear envelope reforms around the chromosomes, and ribosome synthesis resumes.

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