Lead sulfate crystals are highly insoluble in water and most organic solvents. However, they can be dissolved by strong complexing agents such as EDTA or by surfactants that can form micelles and encapsulate the lead sulfate crystals. Some surfactants that have been shown to be effective in dissolving lead sulfate crystals include:

- Sodium dodecyl sulfate (SDS)

- Dodecyltrimethylammonium bromide (DTAB)

- Hexadecyltrimethylammonium bromide (HTAB)

- Cetyltrimethylammonium bromide (CTAB)

These surfactants can form micelles that can encapsulate the lead sulfate crystals and prevent them from precipitating. The surfactants can also help to break up the lead sulfate crystals into smaller particles, which can then be more easily dissolved.