1. Increased Substrate Concentration: Increasing the concentration of the substrate available for the enzyme to act upon will increase the rate of the reaction. This is because there will be more substrate molecules for the enzyme to bind to and convert into product.

2. Increased Enzyme Concentration: Increasing the concentration of the enzyme present in the reaction will also increase the rate of the reaction. This is because there will be more enzyme molecules available to bind to the substrate molecules and convert them into product.

3. Increased Temperature: Increasing the temperature of the reaction will also increase the rate of the reaction. This is because the enzyme molecules will be more active at higher temperatures, which means that they will be able to bind to the substrate molecules and convert them into product more quickly.

In addition to these three factors, there are also a number of other factors that can affect the rate of an enzyme-controlled reaction, such as the pH of the reaction, the presence of inhibitors, and the presence of cofactors.