The solubility of a substance depends on several factors, including the nature of the solute and solvent, temperature, and pressure. Generally, the solubility of a substance increases with increasing temperature and decreasing pressure. The polarity of the solute and solvent also plays a role in solubility. Polar solutes tend to be more soluble in polar solvents, while nonpolar solutes tend to be more soluble in nonpolar solvents.