No, it is not possible to separate a soluble from a liquid. Because solubility refers to the ability of a substance to dissolve in a liquid to form a homogeneous mixture. When a substance is soluble in a liquid, it means that the particles of the substance disperse uniformly throughout the liquid and form a stable solution. In a solution, the solute (the substance being dissolved) and the solvent (the liquid in which the substance is dissolved) coexist as a single phase.

Therefore, you cannot physically separate a soluble from a liquid. If you try to separate them, you will end up with the original solution again. For example, suppose you have salt dissolved in water. If you try to separate the salt from the water by filtration, the salt will pass through the filter paper along with the water. You will not be able to obtain pure salt or pure water from the mixture.