Chromosomes are made up of DNA and proteins, specifically histones, which are located in the nucleus of a cell.

Here's a breakdown:

* DNA: The genetic material that contains the instructions for building and maintaining an organism. It's a long, coiled molecule that looks like a twisted ladder.

* Histones: These are proteins that act like spools around which DNA wraps itself. This wrapping helps to condense the long DNA molecule into a more manageable structure, allowing it to fit within the nucleus.

* Nucleus: The control center of the cell where chromosomes reside.

Together, DNA and histones form a structure called chromatin. Chromatin is the loosely packed form of chromosomes found in the nucleus during most of the cell's life cycle. During cell division, chromatin condenses into tightly packed chromosomes, making them visible under a microscope.

So, to answer your question directly:

* Yes, chromosomes are made up of DNA and protein (specifically histones).

* They are found in the nucleus of a cell.