"Macro-evolution" is a term often used to describe large-scale evolutionary changes, particularly those that result in the origin of new species or higher taxa (like new families, orders, etc.). However, it's important to understand that macro-evolution isn't fundamentally different from micro-evolution – the gradual changes within populations that we see over shorter timescales.

Here's what is true about macro-evolution:

* It's driven by the same mechanisms as micro-evolution: Mutations, genetic drift, gene flow, and natural selection all play a role in both.

* It occurs over longer timescales: Macro-evolutionary changes often take place over many generations and can involve significant changes in the genetic makeup of a population.

* It's a continuous process: There is no clear dividing line between micro-evolution and macro-evolution. They are simply different scales of the same fundamental evolutionary process.

* It's supported by a vast amount of evidence: This includes the fossil record, comparative anatomy, biogeography, and molecular biology.

It's important to note: The term "macro-evolution" is sometimes used in a misleading way to imply that it's a different kind of process than micro-evolution, or that it's somehow less well-supported by evidence. This is not true. The scientific community generally uses the term "evolution" to encompass all levels of change, from small changes within populations to the diversification of life over millions of years.

In summary, macro-evolution is the result of micro-evolutionary processes accumulated over long periods of time. It's not a separate process, but rather a consequence of the same fundamental mechanisms that drive evolution at all scales.