Small molecules that bind with self-proteins to produce antigenic substances are called haptens.

Here's a breakdown:

* Haptens are small molecules that are not antigenic on their own. They are too small to be recognized by the immune system.

* Self-proteins are proteins that are naturally present in the body.

* When a hapten binds to a self-protein, it creates a larger complex that the immune system can recognize. This complex is now considered antigenic, meaning it can trigger an immune response.

Example:

* Penicillin is a common example of a hapten. It can bind to proteins on red blood cells, forming an antigen that triggers an immune response. This can lead to a life-threatening allergic reaction known as penicillin-induced hemolytic anemia.

Let me know if you'd like to know more about haptens or immune responses!