Here's why:
* The ladder: The "rungs" of the DNA ladder are made up of the nitrogenous bases (adenine, thymine, guanine, and cytosine) connected by hydrogen bonds.
* The backbone: The sides of the ladder, or the backbone, are composed of alternating sugar (deoxyribose) and phosphate molecules. These molecules are linked together by phosphodiester bonds.
Here's a simple analogy:
Imagine a ladder. The rungs are the bases, and the sides of the ladder are the sugar-phosphate backbone. The backbone provides structural support and connects the bases.
In summary:
* Inside the ladder: Nitrogenous bases
* Outside the ladder: Sugar-phosphate backbone