* Exchange of matter and energy: Living organisms constantly exchange matter and energy with their surroundings. They take in nutrients and oxygen, and release waste products and heat.

* Not in equilibrium: Closed systems tend towards equilibrium, a state of balance. Living organisms are actively maintaining a state of disequilibrium, requiring a constant flow of matter and energy to sustain life processes.

* Example: A plant takes in sunlight, water, and carbon dioxide to produce food. It releases oxygen as a byproduct. This exchange of matter and energy is essential for its survival.

Closed systems are isolated from their surroundings, meaning they don't exchange matter or energy with the outside world. This makes them very different from living organisms.

Let me know if you'd like more detail on any specific aspect of this!