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  • Inherited Cell Mutations: Understanding Germline Inheritance & Examples
    Germline mutations can be inherited.

    Here's why:

    * Germ cells: These are the cells that give rise to sperm and eggs.

    * Mutations in germ cells: Any mutation that occurs in a germ cell can be passed down to offspring.

    * Inheritance: When a sperm or egg carrying a mutation fertilizes, the mutation becomes part of the fertilized egg's genetic makeup. This means every cell in the developing child will carry the mutation.

    Examples of inherited cell mutations:

    * BRCA1 and BRCA2 mutations: These genes are involved in DNA repair, and mutations in these genes increase the risk of breast, ovarian, and other cancers.

    * Cystic fibrosis: This is a genetic disorder caused by a mutation in the CFTR gene.

    * Huntington's disease: This is a neurodegenerative disease caused by a mutation in the HTT gene.

    Important note: Not all mutations are inherited. Somatic mutations occur in other cells of the body and are not passed on to offspring.

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