Here are a few examples of single-nucleotide changes:
* Substitution: One nucleotide is replaced by another. For example, "A" could be replaced by "T" or "G" or "C".
* Deletion: A single nucleotide is removed from the sequence.
* Insertion: A single nucleotide is added to the sequence.
To provide more specific examples, I need more context:
* What gene or region of DNA are you interested in?
* What is the specific mutation you're looking for?
For example, the most common mutation causing cystic fibrosis is a deletion of a single nucleotide (three-base-pair deletion called ΔF508), which results in the loss of the amino acid phenylalanine at position 508 in the CFTR protein.
Tell me more about the specific mutation you are interested in, and I can give you a more precise answer!