Here are the major differences:
* Sugar: DNA contains deoxyribose sugar, while RNA contains ribose sugar.
* Bases: DNA uses thymine (T), while RNA uses uracil (U) in place of thymine.
* Structure: DNA is typically double-stranded (forming a double helix), while RNA is typically single-stranded.
The similarity: Both DNA and RNA are nucleic acids made up of nucleotides.
Let me know if you'd like more details about any of these differences!