Glycolysis: In the cytoplasm, glucose is broken down into two molecules of pyruvate, releasing a small amount of ATP in the process.
Pyruvate oxidation: Pyruvate from glycolysis is transported into the mitochondria, where it is further broken down and converted into Acetyl CoA.
Citric acid cycle (Krebs cycle): Acetyl CoA enters the citric acid cycle, a series of chemical reactions that result in the release of carbon dioxide, the production of ATP, NADH (nicotinamide adenine dinucleotide), and FADH2 (flavin adenine dinucleotide).
Electron transport chain: NADH and FADH2 from the citric acid cycle carry high-energy electrons to the electron transport chain, a series of protein complexes in the inner mitochondrial membrane. As the electrons pass through the complexes, their energy is used to pump hydrogen ions across the membrane, creating a proton gradient.
Oxidative phosphorylation: The proton gradient created by the electron transport chain generates a flow of hydrogen ions back into the mitochondrial matrix through a structure called ATP synthase. This flow drives the synthesis of ATP from ADP (adenosine diphosphate).
Through these processes, cellular respiration converts the energy stored in organic molecules, such as glucose, into the directly usable form of ATP. ATP is then utilized by the cell to power various energy-requiring processes, including muscle contraction, nerve transmission, protein synthesis, and active transport of molecules across membranes.