Adrenocortical disease (AD) can affect many structures in the body. The organs that the disease is most likely to affect are the skin, the cardiovascular system, and the endocrine system. Here are some of the organs that are commonly affected by adrenocortical disease:

1. Skin: The skin can become thin and fragile, and easily bruise. Darkening of the skin, especially in areas that are exposed to sunlight, is also common.

2. Blood Vessels: High levels of cortisol can lead to high blood pressure (hypertension) and an increased risk of stroke and heart attack.

3. Heart: Adrenal disease can weaken the heart muscle and lead to heart failure.

4. Kidneys: Adrenocortical disease can cause the kidneys to retain sodium and water, leading to fluid retention and edema (swelling).

5. Liver: The liver may become enlarged and fatty. Increased levels of cortisol also increase the production of glucose in the liver, leading to hyperglycemia and diabetes mellitus.

6. Bones: Adrenal disease can lead to osteoporosis, a condition in which the bones become weak and brittle.

7. Adrenal Glands: The adrenal glands themselves may become enlarged or develop tumors, leading to Cushing's syndrome or Addison's disease.