When chromosomes are rearranged, the normal order and spacing of genes can be disrupted. This can affect gene expression, which is the process by which genes are converted into proteins. Gene expression can be increased, decreased, or even turned off if chromosomes are rearranged.
The disruption of gene expression can have a wide range of effects on the organism. For example, a rearrangement that affects a gene essential for development can lead to birth defects or even death. A rearrangement that affects a gene important for immune function can make the organism more susceptible to disease.
Overall, rearranging chromosomes can significantly affect the function of the organism and can have severe consequences.