During cell division, the genetic material in a cell must be precisely replicated and distributed to two daughter cells. To ensure that this process occurs accurately, cells employ a variety of mechanisms to safeguard their genetic information and expedite the activation of essential genes following division. One such mechanism involves bookmarking genes prior to cell division to facilitate their rapid reactivation. This bookmarking process occurs through the binding of specific proteins to the regulatory regions of genes, such as promoters and enhancers. These proteins help maintain an "open" chromatin structure, allowing transcription factors and RNA polymerase to access the gene and initiate transcription promptly after cell division. Additionally, bookmarking proteins can recruit histone modifiers and remodeling complexes to modify the chromatin structure and enhance gene accessibility. This pre-marking of genes enhances their subsequent transcription and contributes to the efficient and timely activation of essential cellular processes after cell division.