The researchers found that a specific type of brain cell, called a pro-opiomelanocortin (POMC) neuron, is responsible for controlling sugar cravings. When these neurons are activated, they release a hormone called alpha-melanocyte-stimulating hormone (alpha-MSH), which suppresses appetite and increases energy expenditure.
The researchers were able to turn off sugar cravings in mice by injecting them with a drug that activates POMC neurons. The drug, called LY2112688, significantly reduced the mice's consumption of sugar water, even when they were given unlimited access to it.
"This study is the first to identify a specific brain cell that is responsible for controlling sugar cravings," said study leader Scripps Research Professor Thomas Kash. "This finding could lead to new treatments for obesity and type 2 diabetes by targeting this cell population."
The researchers say that the next step is to test LY2112688 in humans. If the drug is safe and effective in humans, it could offer a new way to help people lose weight and improve their health.
The study was published in the journal Nature Medicine.
