* Earth: The story begins on Earth, just before its destruction by the Vogons to make way for a hyperspace bypass.
* The Milky Way: The majority of the story takes place within the Milky Way galaxy, with characters traveling to various planets and star systems.
* Other Galaxies: The story also touches upon other galaxies, including the Andromeda Galaxy, where the titular guide is produced.
* The Restaurant at the End of the Universe: A legendary restaurant that exists on the edge of the known universe.
* Deep Thought: A supercomputer, the size of a planet, that calculates the answer to the ultimate question of life, the universe, and everything.
The specific locations are often whimsical and fantastical, including:
* The planet Magrathea: Home to the "Ultimate Question Generator" and a place where planets are custom-built.
* The planet Krikkit: A planet inhabited by a race of blind, but violent, aliens.
* The planet Betelgeuse Seven: A bureaucratic and confusing planet.
* The planet Hactar: Home to the "Restaurant at the End of the Universe."
The series is known for its humor and satire, playing with the concept of space travel and the vastness of the universe. The locations often serve as a backdrop for humorous and absurd situations, highlighting the absurdity of human existence and the search for meaning in the face of the vast and unknowable universe.
