For example, do you mean:
* Charles Darwin: Famous for his theory of evolution by natural selection.
* Charles Babbage: Considered the "father of the computer" for his work on the Analytical Engine.
* Charles Lyell: A geologist who pioneered the concept of uniformitarianism, which argued that geological processes in the past are the same as those occurring today.
* Charles Coulomb: A physicist who studied electrostatics and formulated Coulomb's law, which describes the force between electric charges.
* Charles Goodyear: An inventor who revolutionized the rubber industry by discovering vulcanization.
Once you specify which "Charles" you're interested in, I can provide information about their specific contributions to science.